Sentence examples for binding affinity at the from inspiring English sources

Some binding affinity at the melanocortin receptors MC3 and MC4 was noted.

All synthesized nucleosides exhibited potent and selective binding affinity at the human A3 AR.

5b promoted tubulin polymerization and this was supported by the docking studies, wherein 5b showed significant binding affinity at the colchicine binding pocket of tubulin.

Compounds were also tested for their binding affinity at the DAT by their ability to inhibit binding of [3H]WIN 35, 428.

Twenty-six compounds were used as the training set for comparative molecular field analysis (CoMFA) of antagonist binding affinity at the human β1-AR and also of antagonist potency for rat atrial β1-ARs.

Allosteric modulators have been considered so far as molecules binding to an allosteric site, distinct from that of the reference ligand (orthosteric site), and able to modulate the binding affinity at the orthosteric site and/or the signaling properties resulting from orthosteric site occupancy.

The alleles offering the highest binding affinity at that locus are selected and averaged to provide a prediction of affinity at each locus for the metapopulation in which all alleles are given equal weight.

Several compounds such as 20c (Ki=10 nM) exhibited good binding affinities at the CRF1 receptor.

With exception of the 4′-methylsulfonyl analogue 7h, all the tested compounds possessed high binding affinities at the 5-HTT.

A strong correlation between binding affinities at the (α4 3 β2HQT 2 receptor and functional potencies at the wild-type receptor of a range of nicotinic ligands highlighted the validity of using the mutational approach.

The CoMFA and CoMSIA contour maps identify features important for exhibiting good binding affinities at the transporter, and can thus serve as a useful guide for the design of potential equilibrative nucleoside transporter inhibitors.