Sentence examples for binding affinity as it from inspiring English sources

Presence of two EF hand motifs in ECD of buffalo Smoc-1 is predicted for its calcium binding affinity as it has been confirmed experimentally using circular dichroism in human SMOC-1 [ 18].

As evident from results the OH group of ring A is not involved in hydrogen bonding and therefore its absence in case of 5a increased the binding affinity, while the ortho hydroxyl group of ring B increased binding affinity as it is involved in hydrogen bonding with the target.

We determined binding affinity, as well as solving 1.1 1.6 Å resolution crystal structures of streptavidin bound to Love–Hate ligands.

Biological potencies of the synthesized compounds were assessed in terms of the vitamin D receptor (VDR) binding affinity, as well as the HL-60 cell differentiation-inducing activity.

In several recent studies, these effects have successfully been exploited to manipulate protein scaffolds, resulting in improved catalytic activity and altered substrate or ligand binding affinity, as well as enabling the design of novel biocatalysts and biosensors.

Synthesis and SAR was directed towards the improvement of binding affinity, as well as ADME properties for this new class of p38α inhibitors and ultimately afforded compounds showing good in vivo efficacy.

This array approach facilitated multi-dimensional SAR around this series and identified functionality responsible for binding affinity, as well as opportunities for modulating the overall in vitro profiles of this class of soluble epoxide hydrolase inhibitors.

Much work is being done on radiotracer compounds with high binding affinity as well as faster kinetics which can be used as an aid to visualize the nicotinic receptors and their involvement in neurological disorders [1].

A.sql script (Additional file 9) was developed to extract and insert the corresponding chemical structures, molecular descriptors, ADMET property information, drug target information and binding affinity as well as available literature references into IDAAPM.

Thus every peptide was coupled to a predicted MHC class II binding affinity as well as mean values for α-helix, β-strand, coil and RSA.

The two Ahr alleles encode AHRs that differ by approximately 10-fold in ligand binding affinity, as well as gene induction and gene expression levels, including that of the Cyp1a1 and Cyp1b1 xenobiotic genes (Thomas et al. 2002).