Sentence examples for binding affinity and thus from inspiring English sources

This C/A SNP within the p21 codon 31 results in a substitution of arginine for serine in a conserved region of the protein and may affect the DNA binding affinity and thus physiological function of p21 [ 27].

This led us to the hypothesis that the functional diversity of CTCF may result from its binding affinity, and thus be influenced by the variations in the CTCF binding motifs.

The allowance for receptor flexibility provided by computational techniques such as molecular dynamics simulations or enhanced sampling techniques helps to improve the accuracy of methods used to estimate binding affinities and, thus, such methods can contribute to the discovery of novel drug leads.

Only less than 1% of the peptides differ with more than 10 folds in annotated binding affinity, and the two data sets are thus highly consistent.

Thus, the binding affinity and selectivity conferred on the NetrinG NGL interaction by the specificity determinants we have identified provide the properties necessary to generate and maintain the reported compartmentalization of NGL1 and NGL2 to distinct dendritic subdomains, as proposed for a 'lock-in' type model (Nishimura-Akiyoshi et al, 2007).

Thus, the specific binding affinity and nonspecific binding affinity by a protein typically converge at very low salt concentrations and diverge at high salt concentrations as we observe for the MBD (Table 1).

The presence of the aegPNA monomers in the molecules thus increased the binding affinity and this consequently resulted in a stronger reduction of the gfp signal compared to C2-pePNAs (data not shown).

Thus it can be said that WT structure becomes more flexible upon mutation (T854A) which brings about changes in the binding site of erlotinib thus reducing its binding affinity and rendering the mutated protein to become drug resistant while maintaining its functionality.

The steric properties of the bases in the single-stranded conformation may be such that strong interactions of UP1 with the d nTAGn) sequence are not formed, thus reducing the binding affinity and binding enthalpy change for the control single-stranded sequence used in this study.

Thus higher flexibility of the loop corresponds to lower binding affinity and more facile release of ADP from PKA.

A detailed analysis on protein expression levels for these peroxisomal proteins revealed a remarkable negative correlation between binding affinities and expression levels of cargo proteins, thus providing a mechanistic framework to generating a uniform population of Pex5p-cargo complexes necessary for proper peroxisomal biogenesis [ 28].