Sentence examples for binding affinity and this from inspiring English sources
Many small molecules are known to bind to the troponin complex to modulate its calcium binding affinity, and this may be useful in a broad range of conditions in which striated muscle function is compromised, such as congestive heart failure.
The presence of the aegPNA monomers in the molecules thus increased the binding affinity and this consequently resulted in a stronger reduction of the gfp signal compared to C2-pePNAs (data not shown).
A similar mechanism may occur at rs143383, with methylation increasing the repressive activity of SP3 despite reducing SP3 binding affinity, and this could explain why SP3 represses the methylated 5′UTR luciferase plasmid more strongly than the unmethylated plasmid.
Thus, the fitted affinities and their associated errors are not consistent with the idea that there is a substantial mutation-induced change in TOG binding affinity, and this in turn supports our claim that the conformation of the mutant cannot be very different than that of the wild-type.
However, additional factors might influence its inhibitory activity explaining cases in which there was no correlation between the binding affinity and the activity of this protein.
Computational models rationalize the binding affinity and the inhibition mechanism.
They also exhibit promising DNA-binding affinity and this is supported by molecular modeling studies.
We measured the binding affinity and specificity of this engineered knottin peptide against cell lines expressing particular integrin receptors.
Changes in HA that affect the extent of its glycosylation can also profoundly affect the SA binding affinity and in vivo this may contribute to changes in tropism and pathogenicity [15], [16].
hαCGRP was not used to stimulate the AM1 receptor due to its very low binding affinity and potency at this receptor (McLatchie et al., 1998; Aiyar et al., 2001; Poyner et al., 2002).
Moving one terminal amidine to a meta position (DB2289) results in a dramatic decrease in binding affinity and sequence selectivity, and this indicates that not only the shape of the main scaffold but also the position, molecular curvature, and the distances between two positively charged amidine groups play crucial roles in ligand DNA interaction.
