Sentence examples for binding affinity and therefore from inspiring English sources
Based on the analysis of the predicted 3D structure of Cel8M, it was suggested that changes of K353E and G117S might directly affect the substrate binding affinity and therefore contribute to the improved activities of Cel8ME15 and Cel8ME18.
The initial CDR-grafted antibodies tend to lose the parental binding affinity, and therefore require additional work for back-mutation of several murine framework amino acids, which are regarded to be crucial for CDRs loop conformation [10].
GU81, a derivative of GU40C4, was developed to increase binding affinity and therefore in vitro and in vivo efficacy.
It has been previously demonstrated that CX3CR1 genotypes influence the fractalkine receptor binding affinity and therefore Th1 lymphocytes recruitment.
We also hypothesise that mutating the phosphorylation sites of Ft (so Ft cannot be phosphorylated by Fj) will result in a reduction in binding affinity and therefore a reduced stable amount.
Manipulating these tracts affects TF access to its cognate operator site, which in principle results in modulation of the average TF to DNA binding affinity and, therefore, horizontal scaling of the expression response curve.
The strength of feedback, however, is determined not just by levels of proteins but also by binding affinities, and therefore positive feedback through Gal3p could still dominate expression at the promoters of the Leloir enzymes.
First, when an array contains probe spots for both the forward and reverse target, simple liquid phase kinetics predict that both probe spots ought to have the same binding affinities and therefore should have equal amounts of bound target DNA [ 19].
Coincidentally, the fact that the antibodies that are specific for Ssa showed only slight cross-reactivity with Ssd (0.3%) further suggests that the structural stereochemistry of the 16-hydroxyl group could produce a great variation in their protein-binding affinity and therefore biological activities.
This process will tend to preserve the binding affinity, and ΔS will therefore tend to be zero if the regulatory region is under functional constraint.
11C-SU11274 has the same structure as SU11274, and therefore, its binding affinity and specificity was preserved.
