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Computational models rationalize the binding affinity and the inhibition mechanism.
Figure 3C shows the normalized time-course of trans-binding, illustrating that the rate was influenced by the assembly domain, and Fig. 3D shows the lack of correlation between the apparent binding affinity and the rate at which fluorescence increased.
Docking analysis revealed that the binding affinity and the buried surface area of mEGF to EGFR complex are lower than those of hEGF/EGFR.
The trends in the binding affinity and the surface saturation amount correspond well with the degree of change of protonation of the adsorbed molecules.
The bacteria produced this protein as the pentameric form, which retained the GM1-ganglioside binding affinity and the native antigenicity of CTB and GAD65.
A monomeric ecotin variant (mEcotin) and a single-chain ecotin dimer (scEcotin) were constructed to study the effect of a network of protein interactions on binding affinity and the role of dimerization in broad inhibitor specificity.
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The macromolecular fluorogens were optimized by establishing critical polymer architecture-biophysical property relationships which impacted binding rates, binding affinities, and the level of internalization.
Though the binding affinities and the expression profiles of the BbCRASPs have been studied, the independent role of each BbCRASP in B. burgdorferi infectivity is not clear.
The STAP model is fit by maximizing the Pearson's correlation coefficient between the predicted binding affinities and the overlapping ChIP-seq counts (or ChIP-chip intensities).
Differences between MT201 and trastuzumab may therefore largely relate to their target binding affinities and the biology and quality of the recognised antigens.
This atom-docked model shows an increase in both the binding affinity and in the hydrophobic interactions.
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binding site and the
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binding energy and the
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binding affinity when the
binding surface and the
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binding groove and the
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