Sentence examples for binding affinity and stabilizing from inspiring English sources

Subsequent biophysical and biochemical evaluation demonstrated that the introduction of aniline group at 4-position of quinazoline ring and two side chains with terminal amino group improved their binding affinity and stabilizing ability to G-quadruplex DNA.

Compared with the non-methylated derivatives, 12-N-methylated derivatives had stronger binding affinity and stabilizing ability to c-myc G-quadruplex structure, and could more effectively stack on the G-quartet surface.

Their multiligand chelation ability enhances their binding affinity and stability.

HER2 receptor, which is frequently overexpressed in breast cancer, is a preferential partner of EGFR and the formation of EGFR-HER2 heterodimers potentiates EGFR function by increasing EGF binding affinity, stabilizing and recycling the receptor on the membrane, and expanding the repertoire of intracellular signaling responses [ 95].

In the present study, we found that the C-terminal region (finger and linker) in the artificial ZFPs played a more important role than the N-terminal region in determining their DNA binding affinity, and that the N-terminal fingers could stabilize their binding to the target DNA.

These modified hydrophobic interactions enhance the binding affinity and biological activity of complex molecules and help in stabilizing the biochemical environments of target-drug complexes.

Hydrogen bonds and hydrophobic interaction played a critical role in stabilizing protein-ligand complexes and therefore contributed significantly to improving binding affinity and efficacy of the antimicrobial [ 30].

The results presented here demonstrate that hydrogen bonding and optimized hydrophobic interactions both stabilize the ligands at the target site, and help alter binding affinity and drug efficacy.

Substrate binding stabilizes the subset of conformations involving more intimate interdomain contact and thereby tunes binding affinity and activity.

Computational models rationalize the binding affinity and the inhibition mechanism.

The binding affinity and molecular conformations are discussed.