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Testosterone and DHT both bind to AR, but DHT is more active, displaying greater binding affinity and stabilization of the AR complex [ 23].
Prior to this study, we have found a potential G-quadruplex binder named berbamine from traditional Chinese medicine with moderate binding affinity and stabilization effect on the PDGFR-β G-quadruplex.
Characterization of the binding properties using ESI-MS demonsthateightat eight derivatives displayed remarkably improved binding affinity and stabilization effects on the PDGFR-β G-quadruplex, and bba3Py was the most outstanding one.
This work demonstrates how the design of a family of similar sites within the same scaffold can lead to an understanding of how both the intrinsic properties of the metal center and the surrounding protein matrix can affect the metal binding affinity (and stabilization).
Similar(56)
Hsp90s/HSPCs are required for the degradation, regulation, ligand-binding affinity and stabilization of the androgen receptor, as well as for its trafficking (Peterson and Blagg, 2009).
Their multiligand chelation ability enhances their binding affinity and stability.
Computational models rationalize the binding affinity and the inhibition mechanism.
The binding affinity and molecular conformations are discussed.
The reversibility, binding stoichiometry, binding affinity, and pH sensitivity of the sensor were studied.
11C-SU11274 has the same structure as SU11274, and therefore, its binding affinity and specificity was preserved.
Recognition helix (RH) substitutions change DNA-binding affinity and specificity.
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