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Moreover, the probe 3 has superior binding affinity and sensitivity to Hg2+ over Al3+.
The limit of detection (LOD) and association constant (Ka) revealed that the probe 2 has superior binding affinity and sensitivity to Al3+ over Hg2+.
Interestingly, we find that the nanostructured microsensors exhibited significantly enhanced binding affinity and sensitivity.
Acetylation at K222, K245, K248, K262, K265, K274, and K294 of FOXO1 was also reported to regulate its DNA binding affinity and sensitivity to AKT phosphorylation.
This would suggest that the regulation of endogenous glucocorticoid receptor signalling pathway may be disturbed in MS, which is in concordance with previous evidence of reduced glucocorticoid receptor binding affinity and sensitivity in lymphocytes in MS patients.
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This morphology thus allows higher accessibility of analyte to the nucleic acid, which leads to better observed-binding affinity and sensitivity.
In this work, with the purpose to improve the binding affinities and sensitivities of dipyrrin based fluorescent Zn2+ probes, strongly coordinating pyridyl moieties were introduced into dipyrrins.
The reversibility, binding stoichiometry, binding affinity, and pH sensitivity of the sensor were studied.
The S308V mutantmutant (a mutation which decreases cGMP selectivity in eukaryotic channels) decreased both the observed cGMP binding affinity and the sensitivity to cGMP relative to the wild-type (WT) channel, leaving those for cAMP unchanged.
The HbI-1 and HbI-2 allelic variants differ in oxygen binding affinity and temperature sensitivity and are differentially distributed along a temperature gradient in northeast Atlantic populations [ 34- 36].
One conclusion may be that VH was more important for binding affinity, and VL determined the sensitivity of assay.
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binding affinity and toxicity
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