Both compounds displayed high binding affinity and selectivity to the mu opioid receptor.
Our efforts resulted in new compounds with improved binding affinity and selectivity.
In contrast, the resulting increase in lipophilicity has minimal impact on binding affinity and selectivity.
The compounds 24 26 demonstrated substantial binding affinity and selectivity for A2AR as compared to SCH58261, a standard A2AR antagonist.
These compounds can be used for further development as inhibitors of significant binding affinity and selectivity towards CA VB isozyme.
These pockets can be used to further improve the binding affinity and selectivity of the currently available AKR1C3 inhibitors.
All nucleosides were imprinted, revealing that only those with the 2-aminopyridine substructure show binding affinity and selectivity.
The 2-Cl series generally were better than the 2-H series in view of binding affinity and selectivity.
Noticeably, cyclopentyl-tetrazole (9a) demonstrated good binding affinity and selectivity for CB1 receptor (IC50 = 11.6 nM and CB2/CB1 = 366).
Arylsulfanyl groups at the 5 position of 1,10-phenanthroline are the best side chains regarding binding affinity and selectivity towards G-quadruplex DNA.
Photoaffinity labeling has been used as a promising approach to detection and isolation of carbohydrate-binding proteins, which are typically characterized by low binding affinity and selectivity.
