Sentence examples for binding affinity and receptor from inspiring English sources

Models are useful to predict binding affinity and receptor subtype selectivity of compounds prior to their synthesis, and may find use in rational drug design.

Two most important factors affecting the radiotracer tumor uptake are receptor binding affinity and receptor population.

Fluorescence labeling and immobilization of ligand and/or receptor can disturb the ligand binding affinity and receptor integrity.

However, many factors play a role in tumor uptake and non-target tissue biodistribution of molecular imaging agents, including blood clearance rate, probe stability and metabolism, organ clearance route, tumor washout rate, receptor binding affinity, and receptor binding specificity.

DTPA conjugation has no effect on peptide binding affinity and receptor specificity.

The binding affinity and receptor selectivity of the modified peptide were controlled using the corresponding isolated immobilised integrins.

Their comparable in vivo potency is attributable to their similar receptor binding affinity and receptor-mediated clearance (18).

Individuals with at least one allele containing 7 or more repeats (7R+) show both reduced binding affinities and receptor densities for dopamine neurotransmission in the ascending corticomesolimbic reward pathway that extends from the ventral tegmental area to the nucleus accumbens, prefrontal cortex, and other cortical regions [28].

Individuals with D4.7 repeat show both reduced binding affinities and receptor densities for dopamine neurotransmission [ 31].

Ligand receptor interactions are complex and exactly how these interactions mediate ligand-binding affinity and receptor activation remains largely unknown [ 39].

Compounds 6f, 6g, 11e, 11f, 11g, and 12 showed nanomolar AT1 receptor binding affinity and high AT1 receptor selectivity over AT2 receptor in a preliminary pharmacological evaluation.