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Mutations spread throughout the HA protein have been found to affect receptor binding affinity and preference in the context of other HA subtypes [8], [9], [13], [14], [15], [20].
As Par3, Par6 and aPKC were all tyrosine phosphorylated by Src, it is likely that phosphorylation played an important function in shifting their respective binding affinity and preference for one another and for Numb.
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These results are in good agreement with the strong increase in binding affinity and the preference for BRD4(1) for histone diacetyl marks observed in our in vitro binding studies.
Four polyfluorinated iodine alkanes (PFIs) with specific structural characteristics in iodine substitution and carbon chain length were screened, and the results showed diverse binding affinities and different preferences of these chemicals to ERα or β isoforms.
These receptors exhibit markedly different tissue distributions, DNA binding affinities, and ligand preferences.
Similar negative cooperativity between P3 proline and the novel preference for asparagine in P1 cements our conclusion that non-prime side flexibility greatly impacts MMP binding affinity and cleavage efficiency.
Computational models rationalize the binding affinity and the inhibition mechanism.
The binding affinity and molecular conformations are discussed.
11C-SU11274 has the same structure as SU11274, and therefore, its binding affinity and specificity was preserved.
The reversibility, binding stoichiometry, binding affinity, and pH sensitivity of the sensor were studied.
Their multiligand chelation ability enhances their binding affinity and stability.
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