Suggestions(3)
Exact(2)
Using NMR, we show that I28A leads to altered substrate binding affinity and isomerase activity.
Evidence for this influence consists of the perturbations to backbone chemical shifts, backbone/side-chain mobility, substrate binding affinity, and isomerase activity documented above.
Similar(58)
It was therefore of interest to see whether I28A would have similar responses, in light of its altered substrate binding affinity and cis trans isomerase activity.
Computational models rationalize the binding affinity and the inhibition mechanism.
The binding affinity and molecular conformations are discussed.
The reversibility, binding stoichiometry, binding affinity, and pH sensitivity of the sensor were studied.
11C-SU11274 has the same structure as SU11274, and therefore, its binding affinity and specificity was preserved.
Furthermore, they can display high receptor binding affinity and specificity without the immunogenicity of antibodies [11].
For better binding affinity and selectivity, new analogues of these ligands were made.
Their multiligand chelation ability enhances their binding affinity and stability.
The TR/RXR heterodimer exhibits the highest T3 binding affinity and remains stable during ligand binding.
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CEO of Professional Science Editing for Scientists @ prosciediting.com