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Hence, the lack of oxygens in the structure of PCBs can be correlated to their weaker binding affinity (and consequently their lower molar toxicity).
However, the transport role of the FABPs has tissue dependent differences in ligand specificity and binding affinity, and consequently, in fatty acid metabolism [16].
In fact, this OH is well-known to be very important for ER binding affinity and, consequently, for producing the estrogenic effect.
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Bivalent ligands, in which two identical binding groups are linked by a spacer unit, can have exceptionally high binding affinity, and can, consequently, be useful modulators of biological function.
The presence of the aegPNA monomers in the molecules thus increased the binding affinity and this consequently resulted in a stronger reduction of the gfp signal compared to C2-pePNAs (data not shown).
Although the relationship between Th17 differentiation and the strength of TCR signalling and MHC-binding affinity has not been clarified, it is possible that the difference in amino acid sequences between hGPI325 339 and hGPI544 558 might affect the I-Aq binding affinity and the TCR signalling, and consequently lead to the difference in extent of antigen-specific Th17 cells.
11C-SU11274 has the same structure as SU11274, and therefore, its binding affinity and specificity was preserved.
Computational models rationalize the binding affinity and the inhibition mechanism.
The binding affinity and molecular conformations are discussed.
Furthermore, they can display high receptor binding affinity and specificity without the immunogenicity of antibodies [11].
For better binding affinity and selectivity, new analogues of these ligands were made.
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