Sentence examples for binding affinity and also from inspiring English sources

Using appropriate thermodynamic cycles, our approach predicts the effects of a conformational shift on binding affinity and also allows one to disentangle the effects induced by a conformational shift from other effects influencing the binding affinity.

The small oscillations in the decays and the relative increase at L > 600 thus reflect systematic effects presumably due to differences of the probe properties in the different subensembles of probes referring to each data point such as their binding affinity and also their degradation degree.

Although the binding affinity of each bromodomain with each acetylated lysine is generally weak, it is believed that it has major functional relevance in the cell, due in part to some proteins possessing more than one bromodomain in tandem that synergize to increase binding affinity, and also due to histones possessing multiple acetylated residue that can act combinatorially.

However, in reality, the molecular structural features that increase glucocorticoid receptor binding affinity and selectivity also result in physicochemical and pharmacokinetic changes that together may potentially enhance targeting to the airways and reduce systemic exposure.

Toxic and lethal doses of SEB vary greatly between animal species, mostly because of differences in receptor-binding affinities, and also vary depending on the route of exposure (14 ).

Evaluation of binding to purified enzymes by surface plasmon resonance (measuring on- and off-rates and affinity constants) is the major high through-put tool but isothermal titration calorimetry (ITC, measuring binding affinity and stoichiometry) is also used.

Furthermore, the differences in M. tuberculosis IpsA structure, binding affinity and specificity can also be a reason for the only partial complementation.

We conclude that the known correlation between CD16a binding affinity and ADCC potency is also valid in Fcab proteins and that antigen specific Fcab molecules can be further engineered for fine tuning of immuno effector functions.

Sulfation of CDR tyrosine residues, a property recently shown to broaden antibody binding affinity and antigen recognition was also demonstrated.

Using small peptidomimetics, correlations between higher-order multivalency, receptor binding affinity, and tumor uptake have also been uncovered [44], [45].

Receptor-specific fluorescent ligands with high binding affinity and low off-rates have also been found to be suited for receptor pulse labeling [ 100].