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The study also reports that binding affinities of two distinct fibril edges with respect to incoming Aβ peptides are different.
In order to test the histone binding specificities of other plant MRG chromodomains, we analyzed the binding affinities of two plant MRG chromodomains to various histone peptides via isothermal titration calorimetry.
The binding affinities of two of the six hit fragments, F090 and F152, were determined by measurement of the STD factor variation upon titration.
[16] Herein we report binding affinities of two monovalent blood group oligosaccharides and propose an alternative explanation for the blood-group dependence of cholera.
To analyze the binding affinities of two dysfunctional pol ι variants, Δ1 25 and R96G, for the primer-template DNA substrate in the presence of either Mg2+ or Mn2+, we performed fluorescence polarization experiments.
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The initial human β1-AR model (n=26, q2=0.59, ONC=6, SECV=0.70, r2=0.98, SEnon-CV=0.16, F 6, 19)=148) predicted the binding affinities of seven out of ten test compounds, not included in the training set, with residual pKi values ≤0.50.
Here, the binding affinities of seven aliphatic cyclic ureas to HIV-1 protease are calculated using a predominant states method and an implicit solvent model based upon finite difference solutions of the Poisson-Boltzmann equation.
Here, we performed fluorescence-binding studies and inhibition assay combined with molecular docking and molecular dynamics (MD) simulation analyses to determine the binding affinity of two synthesized triazolo-pyrimidine urea derived (TPUI and TPUII) compounds with CAIX and CAII.
For every peptide locus within the primary amino acid sequence, the predicted binding affinity of two HLA alleles, comprising every possible heterozygous or homozygous pair is considered.
To compare the G-quadruplex binding affinity of two salt forms of TMPyP4 with human telomeric sequence, the fraction of bound G-quadruplex, i.e., the peak area ratio of all [complex] to total G-quadruplex ([complex] and [free G-quadruplex]) [ 27, 33, 34], was used to evaluate the relative binding affinities (RBA; Fig. 3).
Denote by r1 t) and r2 t) the concentration of two regulators, φ1 and φ2 the binding affinity of two regulators from their own target sites, the regulation function can be written as below: (3) d x d t = β k 1 φ 1 r (t ) 1 + k 2 φ 2 r 2 (t ) + k 3 φ 1 φ 2 r 1 (t ) r 2 (t ) 1 + φ 1 r 1 (t ) 1 + φ 2 r 2 (t ) + c - ω x, Considering the general case, a gene is regulated by n regulators.
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