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However the binding affinities of these peptides did not exceed substantially that of NCPERIITL, the most affine peptide tested in the original peptide set (pBL50(exp) = 7.120).
Gel-mobility shift assays revealed very strong binding affinities of these PNAs.
The binding affinities of these bivalent ligands for ERα and ERβ were determined.
The binding affinities of these small molecules with P70-S6K1 & PI3K-δ were performed using AutoDock Vina.
A recent examination of the binding of RNA to designer PPR proteins found that the terminal positions in the target nucleic acids made the least contribution to the binding affinities of these complexes36.
The modest binding affinities of these three radioligands toward α-synuclein were comparable with results from the Thioflavin T fluorescence assay.
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The binding affinity of these compounds for human MT1 and MT2 receptors was determined using 2-[125I]-iodomelatonin 2-[125I]-iodomelatonin 2-[125I]-iodomelatonin
Such analyses indicate that the cationic head of the different compounds must be refined in order to obtain an increase in the binding affinity of these ligands.
Chapter 3 details the synthesis of a new library of greatly simplified bryostatin analogs, and the development and use of a new assay to test the PKC binding affinity of these and other compounds across all conventional and novel PKC isoforms.
In this study, we report on the adsorption of RNA and DNA molecules by exploiting the high binding affinity of these nucleic acids to Ag+ ions anchored on magnetic poly(glycidyl methacrylate) (PGMA) microparticles.
This is consistent with benzylidene anabaseine analogs with OH and NH2 functional groups showing the highest binding affinity of these congeners, and the position of the ligand shown in previous X-ray crystallographic studies of ligand-Ac complexes.
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