Sentence examples for binding affinities of human from inspiring English sources

Comparison of the azole-bound structures provides insight into the relative binding affinities of human and bacterial P450 enzymes to ketoconazole and fluconazole, which can be useful for the rational design of antifungal compounds and specific modulators of human CYP51.

The binding affinities of human histamine H3 antagonists were predicted using an enhancement replacement method – partial least squares (ERM-PLS) model and the results were compared with those of genetic algorithm (GA -PLS and stepwise linear reGA -PLSn (SW)-PLS models.

We assembled a dictionary of 2935 motifs representing empirically-determined binding affinities of human and/or mouse TFs and uDBPs.

The binding affinity of human CYP24A1 for A-ring diastereomers was (1α,3β) > (1α,3α) > (1β,3β) > (1β,3α), indicating that both hydroxyl groups at C-1 and C-3 positions significantly affect substrate-binding.

For example, this plasticity could slightly modulate the binding affinity of human CNTN5 and -6 for PTPRG and thus modify its intracellular phosphatase activity.

Glycoengineering is a process used to manufacture antibodies lacking core fucose, which results in significantly higher binding affinity of human IgG1 antibodies to human FcγRIIIa, and consequently greatly enhanced ADCC activity.

Our data clearly indicate that residues 125 and 140 play critical roles governing the differential AZ-binding affinities of human ODC and AZI.

Thus, the apparent binding affinities of the human N-terminal domains at p Ca > 8 are in the order huC0C2 ∼ huC1C2 > huC0C1.

First, all 51 promoter SNPs within the 230 kb LD block in chromosome 1q were evaluated for their potential to affect the binding affinities of known human transcription factors.

Surface plasmon resonance measurements revealed high binding affinities of belatacept to human and mouse CD80 as well as CD86 [13, 13].

Here we evaluate the performance of a molecular dynamics based method for predicting the binding affinities of different types of human thrombin inhibitors.