Sentence examples for binding activity suggesting that from inspiring English sources

Pre-treatment with ESL inhibited the TPA-stimulated NF-κB binding activity, but not the AP-1 binding activity, suggesting that ESL specifically blocks NF-κB activation in MCF-7 cells.

The R458A and R458K mutations showed similar impact on mCpG-dependent binding activity, suggesting that charge on the residue is not critical.

Compared to Tip110, both ΔRRM and Tip110s showed no binding to U6 RNA, while ΔNLS retained the U6 binding activity, suggesting that RRMs were directly involved in Tip110 binding to U6 RNA.

The rest suffer from poor expression and lack reproducible binding activity, suggesting that any use of these SH2 domains in high-throughput in vitro binding studies may yield erroneous results.

In contrast, TP53 inactivation in association with wild-type SMAD4 was highly enriched for nonsense, deletion, or frameshift mutations that abolish p53's DNA binding activity, suggesting that loss of SMAD4 during PanIN progression is selected for because of its cytostatic and apoptotic functions conferred by its own ability to bind DNA in association with SMAD2 or SMAD3 [ 51, 52].

Localization of BSCTV C4 protein and its DNA binding activity suggest that BSCTV C4 function as a nuclear shuttle protein to bind viral DNA and mediate the movement of virus between nucleus and cytosol.

In the same figure, the signal of phage displaying scFv anti-p17 mutant (M100R and M100G) was higher than that of scFv wild type reflected the higher binding activity suggested that both mutants can improve the binding affinity with the peptide.

Our results show that GLAST activity triggers Ca2+ influx, and increases mTOR phosphorylation and AP-1 (activator protein-1) DNA-binding activity, suggesting that Glu imbalance could alter the translation of proteins involved in gene regulation in the retina.

Both GW7647 and oleic acid function as PPAR agonists, and both inhibit MSI1 RNA-binding activity, suggesting that MSI1 and PPARs possibly regulate gene expression in a reciprocal fashion.

After treatment with high glucose (1 and 3 h) and TNF-α (up to 24 h), but not with high mannitol or sodium chloride, we observed a time-dependent increase in NF-κB DNA-binding activity, suggesting that this transcription factor can cooperate to the expression of the COX-2 gene by high glucose, but not in response to high glucose-related hyperosmotic stress (Fig.  5b c).

The ubiquitous taxonomic distribution of Bet v 1-like superfamily members and their ligand binding activities suggest that the Bet v 1 fold can be traced back to the last universal common ancestor and that the primordial Bet v 1-like protein probably functioned as a lipid carrier.