Sentence examples for binding activity required to from inspiring English sources
The anti-aggregation effects of profilin depend on both its polyproline binding activity (required to bind Htt), and its ability to bind G-actin (required to suppress both Htt and AR aggregation) [29].
This binding activity requires a conserved arginine residue in the Ig-like V-set domain.
The two ElbaC proteins also resemble the corresponding full-length Elba1 and Elba2 proteins in that full DNA binding activity requires the dimerization activity of the GST (compare Figure 6A, lanes 13 13).
This suggests the tenfold increase in GAP activity, occurring on Sec13/31 binding, is required to overcome the approximate tenfold ratio of Sec12 GEF activity to Sec23/24 GAP activity to drive COPII uncoating once fission is complete (Futai et al. 2004).
Thus, the MF terms for types of 'nucleic acid binding transcription factor activity' are required to have 'has_part' relationships to the appropriate MF terms for 'nucleic acid binding' [e.g. 'sequence-specific DNA binding RNA polymerase II transcription factor activity' (GO 0000981) has_part 'RNA polymerase II regulatory region sequence-specific DNA binding' (GO 0000977)] (see Figure 1).
As in the case of PP5, substrate binding is required to stimulate the activity of DUSP1, DUSP2, DUSP6 and DUSP9.
Importantly, the DNA binding activity of POT1 is required to prevent the limited processing of the 3' telomeric overhang by WRN, since POT1Δ is unable to repress WRN exonuclease activity on both substrates.
Although there is unambiguous evidence that several EUL domains possess carbohydrate-binding activity further research is required to corroborate the carbohydrate-binding properties of different members of the EUL family.
Along with the recognition of methylated lysines by the MBT domain, the RNA-binding activity of the RBR is required to recruit or stabilize SCML2 on chromatin.
Like Cfp1, the Mll1/2 proteins encode a ZF-CxxC domain that can bind to non-methylated DNA and in some instances this DNA binding activity is required for the functionality of the Mll protein.
Since the hetero-tripartite complex is required to reconstitute DNA binding activity, Elba insulating activity would be expected to peak during the blastoderm/early gastrula stage when high levels of elba1 and elba3 mRNA are expressed.
