Sentence examples for binding activity of several from inspiring English sources
They mainly act by inducing oxidative stress, which activates several proto-oncogenes, like FOS and MYC, and enhances the DNA binding activity of several transcription factors, such as NF-κB and AP-1 [ 5, 6].
Following purification, the binding activity of several scFv antibodies were quantified using a novel Biacore assay.
We report here the use of multiple stabilizing substitutions to increase the stability of p16INK4a and furthermore, to restore Cdk4 binding activity of several defective, cancer-related mutant proteins.
Pituitary hormone prolactin administration directly or indirectly increases the number of proliferating cells during the priming stage of hepatectomy, which causes an increase in the binding activity of several TFs involved in cell proliferation, liver-specific differentiation, and the maintenance of energetic metabolism (Olazabal et al., 2009).
This was followed by further studies on PfRH1 [22] and PfRH4 [24], which mapped the receptor binding region by analyzing the binding activity of several overlapping fragments of the PfRH proteins.
In order to experimentally validate the computational predictions Western blotting experiments of nuclear proteins and EMSA band shift assays were carried out to determine the DNA binding activity of several transcription factors.
It has been reported that in several injury models, injury leads to significant changes in binding activities of several liver-enriched transcription factors, including HNF4α [ 18- 20].
We have shown that altered levels of SOD2 reveal a sensitivity to oxidative stress created by 2ME2 treatment and result in perturbations in the binding activities of several transcription factors, decreased phosphorylation of VEGFR2, and the alteration of the expression of several genes.
To directly test whether DNA-binding is involved in the differential activities of cHES6-1 and cHES6-2, we next electroporated variants of these proteins where two arginines from the C-terminus of the basic domain were replaced by uncharged amino acids (AQ), an alteration that has been shown to abolish the DNA-binding activity of several bHLH proteins [11], [13], [38] [44].
In the present study, we investigated the expression, the subcellular distribution and the microtubule-binding activities of several MAPs in SY5Y cells upon differentiation.
Extensive biophysical studies indicate that the hyperstable substitutions enhance the binding activity of mutant p16 through several different mechanisms, including an increased amount of secondary structure and thermostability, reduction in exposed hydrophobic surface(s) and/or a reduced tendency to aggregate.
