Sentence examples for binding activity of bHLH from inspiring English sources

The DNA binding activity of bHLH proteins is mainly determined by the basic region [ 2].

In 2002, Ledent et al. [ 4] defined 44 orthologous families or sub-families and 6 supergroups based on the DNA-binding activities of bHLH transcription factors after large-scale phylogenetic analyses.

Hetero- or homo-dimerization-dependent DNA binding activity of class A bHLH proteins are regulated to a large part by the class D HLH inhibitors of differentiation (Id) gene family [ 2].

To directly test whether DNA-binding is involved in the differential activities of cHES6-1 and cHES6-2, we next electroporated variants of these proteins where two arginines from the C-terminus of the basic domain were replaced by uncharged amino acids (AQ), an alteration that has been shown to abolish the DNA-binding activity of several bHLH proteins [11], [13], [38] [44].

Binding activity of dust samples.

Since Hes1 is a bHLH protein and suggested to serve as an inhibitor of E proteins [33], [34], we tested its ability to influence the DNA binding activities of E proteins using electrophoretic mobility shift assays and an E-box probe.

The DNA-binding activity of target genes is determined in the basic region of the bHLH domain [ 6].

(c) DNA-binding activity of NucS.

Snail, Slug, and Scratch all bind to E-box sequences (CANNTG) and can antagonize the activity of bHLH proteins [8], [28] [31].

Generally Id proteins have been found to antagonize the activity of bHLH proteins, and in particular of E2A.

The DNA-binding activities of PIFs are also modulated by the tripartite HLH/bHLH module, in which the PRE family of non-DNA binding HLH factors sequesters another class of HLH factors (including IBH1 and PAR1), which otherwise inhibit DNA-binding of bHLH factors including HBI1 and PIFs (Hao et al., 2012; Ikeda et al., 2012; Bai et al., 2012a).