Sentence examples for binding activity observed in from inspiring English sources

First, in biotinylated histone peptide pull-down assays, MPP8CD, TDRD7TD, and JMJ2CTD, all reproduced the binding activity observed in the screen (Fig. 4c).

Moreover, these triple mutants do not display the afternoon-phased DNA binding activity observed in wild-type plants.

The N-terminal region contains a Trx-like domain and a histidine-rich region that may potentially account for the membrane binding activity observed in both Bf.SelP_a and 3NSelP.

As illustrated in Figure 2A, the increase in NF- κB-DNA binding activity observed in U937-Neo cells exposed to TNF- α (lane 2), as compared to nonexposed cells (lane 1), was no longer observed in U937-hGH cells treated under similar conditions (lanes 4 and 3, respectively).

In order to determine whether the increased nuclear NF-κB DNA-binding activity observed in response to prostratin+VPA versus prostratin treatment resulted from an increased degradation of cytoplasmic IκBα, we monitored the presence of IκBα as a function of time in the cytoplasm after treatment with TNFα, prostratin, VPA or prostratin+VPA.

The slight reduction in ligand binding activity observed using the highly accurate and precise assay in this study is not critical for initial biopharmaceutical product development, including biophysical and biochemical characterization and biopotency assays.

The reduced C1q binding and CDC activity observed in these studies may also reflect the lack of terminal galactose in these highly mannosylated forms.

Selected peptides make specific contacts with the effector-binding region of Gα, which may explain an interesting bifunctional activity observed in GSP.

Consistent with the low activity observed in phospho-mimics installed at T287, the conformation of the P+1 loop is suboptimal for substrate binding.

Although the results do not fully capture the correlation between the type of zinc-ligand and inhibitor activity observed in structure-activity studies, (phosphinate > carboxylate > sulfhydryl) [18], perhaps the negative activity attributed to the phosphinate oxygen atoms reflects its weak zinc-binding ability in comparison to the other zinc binding groups.

The lowering of the concentration of Tb-core wasupporteded by the lowered binding activity (∼50% active) observed in the gel shift assay.