Sentence examples for binding activity may be from inspiring English sources

Another outcome of inhibiting the DNA binding activity may be to promote apoptosis by preventing repair under conditions of extreme DNA damage.

These observations suggest that the balance between the nuclear and cytoplasmic QKI isoforms and/or the QKI RNA binding activity may be regulated by signaling pathways.

Actin filament binding activity may be a major contributor to the subcellular localization of lasp-2 to filopodia but is not crucial for lasp-2 recruitment to focal adhesions.

While we are aware that IGFBP-2 is overexpressed in some cancers and it has been suggested that it may promote tumorigenesis (Mehrian-Shai et al, 2007; So et al, 2008; Degraff et al, 2009; Foulstone et al, 2013), our findings suggest that IGFBP-2 lacking IGF-dependent (proteolysis) and IGF-independent (matrix binding) activities may be effective for the treatment of cancers in the future.

Apart from IGF-dependent (proteolysis) activities, IGFBPs also have IGF-independent activities in relation to cancer; mutants lacking both proteolysis and matrix-binding activities may be effective for the treatment of cancers in the future.

The cellular localization of the two mutant EspGs suggests that ARF binding and RabGAP activity may be required for the correct localization of EspG in REs as well as the correct functioning of the protein.

The primary mechanism by which PRO 2000 inhibits HIV infection is binding to viral gp120, although some activity may be attributed to binding to CD4 receptors on target immune cells [19].

However, the similarity of YAP and TAZ in TEAD-binding suggests that TAZ activity may be regulated by miR-130a in a similar fashion.

Chymotrypsin-like activity of the proteasome results in the generation of peptides with hydrophobic C-terminal residues that facilitate MHC class I binding (32), whereas caspase-like activity may be responsible for destruction of CTL epitopes (33).

T3-induced PI3K activity may be initiated by binding to membrane-bound integrin αv β3 or via a mechanism that is cytoplasmic in origin and 1(d)) [ 57].

It has been postulated that this lowered Fc activity may have resulted in poorer efficacy in intestinal bowel diseases, where the Fc activity may be important for binding cell surface-associated TNF-α [ 145].