Sentence examples for binding activity is required from inspiring English sources

Like Cfp1, the Mll1/2 proteins encode a ZF-CxxC domain that can bind to non-methylated DNA and in some instances this DNA binding activity is required for the functionality of the Mll protein.

Similarly, it seems that ETS1 activation is required for angiogenesis by sprouting of mature endothelial cells and down-regulation of ETS DNA binding activity is required for increased VPC differentiation from their progenitors as shown in this study.

Taken together, our results suggest that CPAP is a positive regulator of ciliogenesis whose intrinsic tubulin-dimer binding activity is required for cilia formation in neuronal cells.

Together, our results imply that CPAP acts as a positive regulator in cilia biogenesis and its intrinsic tubulin-dimer binding activity is required for ciliary microtubule assembly during cilia biogenesis.

In this study, we establish a cell system to examine the roles of CPAP during ciliogenesis and show that CPAP may directly regulate cilia length and its intrinsic tubulin-dimer binding activity is required for cilia formation in neuronal cells.

Other technologies like cell-based assays, biacore, and homogeneous mobility shift assays can characterize the functionality of anti-drug antibodies; however, the question arises whether characterization of the antibody binding activity is required, when this can be easily answered with a simple ELISA test due to the fact that the immune response detected by ELISA is neutralizing.

To explore whether intrinsic Smad4 DNA-binding activity is required for promoter activation, we used a Smad4-deficient cell line, MDA-MB-468.

Murley et al. demonstrate that the GTPase activity of this protein, but not its calcium-binding activity, is required for the final release of ER mitochondria contacts, which is consistent with the results of mitochondrial inheritance studies (Koshiba et al., 2011).

Here, we demonstrate that buffering by RNA chaperones occurs at the organismal level, establish that helicase and nucleic acid-binding activity are required for buffering by DBRHs and CspA, respectively, and identify individual mutations that are amenable to buffering.

Both ULK3 kinase and ESCRT-III-binding activities are required for abscission regulation and our data support a model in which ULK3 phosphorylates ESCRT-III proteins, and thereby, delays the membrane cleavage step of abscission.

In the case of HER-2 which lacks the domain/ability for ligand-binding, its kinase activity is required for nuclear entry (Wang et al, 2004).