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Identification of small molecules that specifically inhibit protein-DNA binding activity has had some success [16], [17], [18], [19].
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YY1 is a transcription factor, and its DNA binding activity has been well characterized.
Within the data set, there are 155 proteins that have binding activity, 87 that have catalytic activity, 25 that have molecular transducer activity, 24 that have transcriptional regulatory activity, 16 that have enzyme regulatory activity, 6 that have transporter activity, 5 that have structural molecule activity, 1 that has electron carrier activity, and 5 with no known molecular function.
Certain general design principles to optimise their binding and biological activity have emerged in recent years.
Activity has remained subdued this year.
Activity has been picking up.
GO molecular function analysis revealed that genes encoding proteins having DNA binding, sequence-specific DNA binding transcription factor activity, nuclease activity had a lower percentage of AS, and the gene coding proteins for protein binding and having kinase activity had a higher percentage of AS in the majority of plants (Table 7).
Several SR binding sites having enhancing activity have also been identified and studied in the constitutive β-globin exon 2 [29], and other observations have demonstrated a linear correlation between splicing efficiency and the number of enhancer elements present [65].
Their DNA-binding ability and cytotoxic activity have been evaluated.
Nearly a dozen DNA binding proteins that have insulator/architectural activity have been discovered.
In addition, this protein has binding activity to mannose in a Ca2+-dependent manner.
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