Charged amino acids, especially basic amino acids, have previously been suggested as a key component of nucleic acid-binding activity; for example, arginine-rich regions of the Drosophila melanogaster suppressor of sable gene are thought to mediate specific RNA-binding activity.
These proteins were involved in binding, structural molecule activity, and antioxidant activity, for example.
The presynaptic trace x+ tracks past presynaptic activity, for example, glutamate binding to postsynaptic NMDA receptors.
These mutations impair imatinib activity, for example by interfering with an imatinib binding site or by stabilizing a conformation of BCR-ABL with reduced affinity to imatinib.
An alternative BRAF fluorescent ligand binding assay gave much lower K d values than the IC50s for the V600EBRAF kinase activity (for example: compound 1h, K d = 6.1 nM whereas IC50 BRAF = 230 nM).
Genes with a wide range of predicted functions are down-regulated, but amongst these are a number encoding RNA-binding or processing activities; for example, an argonaute protein (Cluster024059) and an RNA-helicase (Cluster023450).
Take extracurricular activities, for example.
Physical activities, for example, had to compete with other activities.
Complexing may be required to fulfill a basic function (e.g., proper binding of tumor necrosis factor) or to synergize activity through, for example, altered binding affinities.
Culture-dependent changes in nutrient availability could, for example, modify plasminogen binding activity through associated changes in cell wall protein expression or their surface accessibility.
