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This activity could explain the immunosuppressive effects of glucocorticoids [66].
Not even a twofold increase in sports and leisure activities could explain the higher incidence.
However, in both cases residual binding activity could be detected.
The mechanism of antimicrobial activity against bacteria was mostly via permeabilization of the membrane and DNA binding, which could explain the antimicrobial activity of human milk (Hakansson 2015).
Therefore, we were interested to know whether the nuclease activity associated with its promiscuous DNA binding could explain Cre's pleotropic effects.
The available structures of A3A and four other APOBECs [ 44– 48] show no obvious features within the C- or mC-binding pocket that could explain the observed difference in mC deamination activity of A3A, A3BCD2 and other APOBECs.
The elevated activity of CAP could explain the elevated activity of complement factor I as well.
A similar mechanism may occur at rs143383, with methylation increasing the repressive activity of SP3 despite reducing SP3 binding affinity, and this could explain why SP3 represses the methylated 5′UTR luciferase plasmid more strongly than the unmethylated plasmid.
This activity could help explain the remarkable resistance of healthy mucosal surfaces to chronic infections.
Differences in physical activity could also explain the observed differences in lung function.
Changes in apoptotic activity could also explain the reduced number of CIA BMMs (Fig. 5).
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