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Thus, even a specific inhibition of their RNA binding activity can affect several different functions.
It is well known that (but not understood how) residues far away from Hsp90's nucleotide binding pocket can regulate its ATPase activity, a phenomenon called allosteric regulation.
Cold inducible RNA binding proteins (CIRBP) are stress proteins with RNA binding domain that can regulate cellular activity under stressful conditions such as hypoxia [ 33] or during brief periods of osmotic stress [ 34] in fish.
It has been shown that RNA accessory proteins such as RNA binding proteins (RBPs) can regulate miRNA activity without impacting miRNA expression levels and blur the relationship between miRNA activity and miRNA expression [ 11].
Indeed, X-ray crystallography indicates that COUP-TFII contains a ligand-binding pocket whose activity can be regulated by small diffusible ligands [ 36].
Moderate physical activity can help regulate your mind and body.
Zhang et al. have pursued an alternative approach by developing inhibitors that can regulate kinase activity by binding outside of the ATP-binding site.
Apparently, other USP enzymes can regulate USP4 activity by competing for binding to the Ubl domain.
In the native ECM, VEGF activity can be regulated via binding to ECM components, such as heparan sulfate proteoglycans (HSPGs) and collagens.
For example, the binding of α-parvin to the ILK catalytic domain results in the inhibition of the kinase activity, suggesting that dynamic protein-protein interactions within cells can regulate ILK kinase activity.
Furthermore, insulin can regulate eNOS activity through a calcium ion-independent way32.
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