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Conversely, secreted binding proteins can block the activity of previously active extracellular factors [ 5].
Here we sought to use the exploratory potential of mAb to identify a binding site that can block the polymerization of Z α1-antitrypsin without loss of inhibitory activity.
VEGF binding activity was blocked by 6a-P in embryonic mouse brain, lung and kidney (Supplemental Figure S2).
Its binding activity and blocking potency for human and cynomolgus monkey CD40 were similar.
Phosphorylation or acetylation that can block FoxO activity may alter the binding of the C-terminal basic region to DNA to prevent transcriptional activity [ 27].
ER has been shown to block NF-κB activity at several steps: (a) it can inhibit the IKK activity; (b) it can inhibit degradation of I κB; (c) it can block DNA binding by NF-κB; (d) it can bind coactivators and compete with NF-κB for coactivators binding; and (e) it can directly bind to DNA-bound NF-κB to inhibit NF-κB-mediated transcriptional activation.
It was shown that a change from RGD to RAD can block the binding and thus disintegrin activity of the peptide [ 56].
After binding to a receptor, an antagonist can block the effect of an agonist.
Morpholinos can block ribozyme activity.
These results confirm that R53 can block CD4 binding to gp120.
Their roles in regulating the acetyltransferase activity and substrate specificity, as well as identification of compounds that can block or mimic ligand binding, are topics of ongoing study.
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