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Deacetylation of sequence-specific transcription factors can decrease their DNA binding activity and subsequently may repress transcription.
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CSD possesses nucleic acid binding activity and is capable of binding to single-stranded DNA/RNA and double-stranded DNA19.
Also, celecoxib treatment reduced both Sp1 DNA binding activity and transactivating activity.
Molecular Function = nucleic acid binding activity, nucleotide binding activity, RNA and DNA binding activity, and transcription factor activity.
Tyrosinases hydroxylate monophenols to form ortho-diphenols (monophenolase activity) and subsequently oxidize the o-diphenols to o-quinones (diphenolase activity).
16 Fosfomycin is a phosphonic acid derivative that exhibits bactericidal antimicrobial activity by binding to and subsequently inhibiting uridine diphosphate (UDP -N-acetylglucosamine enolpyrUDP -N-acetylglucosamineyme involved in early-stage peptidoglycan synthesis.
Wheat cold-shock domain protein 1 (WCSP1) also has nucleic acid binding activity, anti-termination activity and dsDNA melting activity18.
Functional enrichment analysis of differentially methylated genes involved in transporter activity, translation regulator activity, catalytic activity, receptor activity, signal transducer activity, structural molecule activity and binding activity with their respective percentages given.
These observations raise the possibility that NIS expression, and subsequently iodide transport, are reduced in thyroid tumors at least in part owing to alterations in the binding activity of AP2 and Sp1 transcription factors to NIS promoter.
Iduna is a PAR polymer-binding protein, and mutation at the PAR polymer binding site abolishes the PAR binding activity of Iduna and attenuates its protective actions.
Hsf trimerization via the formation of a triple stranded alpha-helical coiled-coil is a prerequisite for high affinity DNA binding and, subsequently, for transcriptional activity.
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