Sentence examples for binding activity and selectivity from inspiring English sources

The present investigation expands on the study of structure activity relationships of prototype compound 2 by constraining the molecule into a macrocyclic structure with the aim of improving its G-quadruplex binding activity and selectivity.

Application of our scFv homodimer conjugate reveals that CEA binding activity and selectivity is maintained after conjugation, with a shift in fluorescence being observed only on the A375CEA cell line.

Further investigation in this field, perhaps with a detailed crystal structure of IRP2 complexed with IRE, will hopefully determine the specificity of the IRE IRP interaction, the preferential binding of individual IRPs to a subset of IREs and the effects of IRP modification on its binding activity and selectivity.

The successful immobilization of recombinant protein A from Staphylococcus aureus with the C-terminal cysteine residue (SPA-Cys) on the nanolayer gold sensor surface of the SPR spectrometer while preserving its high immunoglobulin-binding activity and selectivity of the sensor response has been performed.

This presentation will describe how structural biology, molecular pharmacology, and medicinal chemistry studies can be combined with molecular modeling and chemoinformatics analyses for a more accurate description and prediction of structural determinants of protein-ligand binding, functional activity, and selectivity.

It was found that compound 14c with the highest COX-2 activity and selectivity exhibited a binding pattern and interactions similar to that of celecoxib with formation of more hydrogen-bond features.

Structure activity relationship (SAR) information suggested that the extended conjugated system of the pyranoxanthone skeleton facilitates the interaction of the small DCX molecule within the viral binding pocket, consequently leading to enhanced anti-HIV activity and selectivity.

The information obtained from this work can be utilized to accurately predict the binding affinity of related analogues and also facilitate future rational designs of novel PDE5 inhibitors with improved activity and selectivity.

As a result, it can lead to unique slow tight-binding kinetics for the β-hydroxymethyl chalcone in HDAC2 but not in HDAC1, and the inhibitory activity and selectivity are increased due to the longer target-resident time in HDAC2.

Docking experiments and SAR highlighted the possible binding mode of these compounds to the enzyme, putting the background for the future optimization of their inhibitory activity and selectivity towards the closely related enzyme PTP-1B.

Phenyl at this position reduced activity and selectivity while pushing the side-chains of Lys-391 and Asp-500 away from the binding pocket.