As mentioned, MT may participate in regulating p53 stability and DNA-binding activity, and in protecting cells against cadmium-induced toxicity, p53-induced reactive oxygen intermediates, and apoptotic DNA damage.
Antibody binding activity and specificity were evaluated by ELISA.
Molecular Function = nucleic acid binding activity, nucleotide binding activity, RNA and DNA binding activity, and transcription factor activity.
However, those actin filaments are often bound with tropomyosin (Gunning et al., 2008), which inhibits binding of cofilin and protects the filaments from cofilin's severing and depolymerizing activities (Bernstein and Bamburg, 1982; Ono and Ono, 2002).
In this study we used cellular, chemical, and computational approaches to evaluate the hypothesis that Ybt's previously documented copper-binding activity protects UPEC during phagocytosis.
The nuclear staining of SPRR2 in the human epidermis is consistent with the nuclear localization and DNA binding activity of SPRR2 that protects DNA from ROS damage (Vermeij et al, 2012).
On the basis of our findings, we propose here that Prdx1 promotes PTEN tumour suppressive function by binding PTEN and protecting its lipid phosphatase activity from H2O2-induced inactivation.
HSC70 plays an important role in binding and protecting peptide for MHC class II molecules [30].
Catalytic activity included transferase and hydrolase activities and binding activity included DNA, RNA, nucleotide, and protein binding.
Aptamer binding stabilizes the DNA aptamer and protects it from enzymatic cleavage [ 158].
