Sentence examples for binding active from inspiring English sources

Each optimization step was quantified and the ligand binding active fraction of the receptor samples could drastically be improved.

Thus, for high-affinity binding, active phospho-receptor needs to disrupt key interactions that support basal conformation (Gurevich and Gurevich, 2004), thereby making arrestin more flexible.

For comparison, this was done with both the binding (active) form, cys-anxA5, 5 and the non-binding (inactive) form, M1234-cys-anxA5.

Even in the presence of high BBB permeability, factors such as high plasma protein binding, active efflux across the BBB, and metabolism within the CNS can greatly limit the ultimate concentrations achieved.

The novel series of substituted 6-anilinoindazoles were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of the compounds crystallized into the JNK3 ATP binding active site.

In this review we discuss the utility of protein-structure-based design and docking approaches aimed at overcoming issues related to plasma protein binding, active transport via P-glycoprotein, hERG channel mediated cardiotoxicity and cytochrome P450 inhibition, metabolism and induction.

The Tf-Tf receptor pathway opens a possible avenue for novel targeted cancer therapy by utilizing Tf-binding active compounds.

Because of a highly conserved motif resembling the zinc-binding active site of nucleotide deaminases and essential for editing, the DYW motif of PPR protein was hypothesized to be responsible for the catalytic reaction but is still debated (Boussardon et al. 2014; Takenaka et al. 2014; Yagi et al. 2013; Wagoner et al. 2015).

The prior modeling studies also revealed the basis for partial cross-resistance of LVDr HBV to ETV since the pocket accessed by ETV was partly reduced in HBV with LVDr substitutions of the tyrosine-methionine-aspartate-aspartate (YMDD) dNTP-binding active site loop of the polymerase [3].

In structural terms, all canonical poly(A) polymerases share a conserved N-terminal 450 500 amino acids that includes crucial RNA-binding domains, Mg-coordinating amino acid side chains, the ATP-binding active site of the enzyme, and nuclear localization signals [4], [5].

Of the 26 residues lining the ATP-binding active site, only three were variant and all were specific to Aurora-A.