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In contrast, when the wild-type was cultured in DMEM it showed the same intensity of NF-κB NF-κBP-1 DNandinding activation compareDNAo the EDL933ΔhcpA cultured in DMEM or Minca (Fig. 9A and binding
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These studies demonstrate that the variant PPARA promoter sequence exhibits diminished ERR binding and decreased ERR-mediated transcriptional activation, compared to the wild-type PPARA −54,642 G allele.
These results indicate that the Y516F mutation compromises guanine nucleotide binding which results in a lower Ca2+ threshold for the activation of transamidating activity compared to wild type TG2.
Two branched N-terminal VIP sequences demonstrated superior receptor binding and activation as compared to two N-terminals in tandem.
Simulation results for stationary insulin receptor activation and insulin binding were compared to experimental data sets [ 57].
Notably, Half DVD-Ig molecules that are monovalent for each specificity demonstrated reduced non-specific CTL activation and conditional CTL activation upon binding to TAA compared to intact tetravalent DVD-Ig molecules that are bivalent for each specificity, while maintaining good drug like properties and appropriate PK properties.
They cluster around the ATP-binding pocket of the tyrosine kinase domain of EGFR, leading to ligand-independent activation of the receptor and longer activation time compared to wild-type EGFR.
4-NP-β-mannoside also showed a higher maximal activation as compared to the corresponding glucoside.
LZ modification greatly enhanced DM-catalyzed peptide binding to DR1 compared to unmodified soluble DM and DR1.
The single variants N59D and A158T supported binding but showed little change in the free energy of activation by MgADP compared to the wild type TtPFK.
Indeed, CSA 8M showed greatly increased binding to TCP1 when compared to CSA WT (Fig. 5c).
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