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Subsequent biophysical and biochemical evaluation demonstrated that the addition of pyridine ring and amino group into berberine improved the binding ability and selectivity towards G-quadruplex DNA in comparison with the previously reported 9-N-substituted berberine derivatives.
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The moderate binding ability and unobvious DNA cleavage ability account for their low toxicity towards DNA.
It is also well known for its binding ability and used in preparing good inks to make carbon electrodes providing binding ability along with good electronic conductivity.
Their DNA-binding ability and cytotoxic activity have been evaluated.
Herein, we report the synthesis of novel locostatin-based chemical PEBP probes and evaluate their ability and selectivity towards the binding of FT and RKIP.
We assessed selectivity of phage bacteria-binding by comphage bacteria-bindinglity of the selected clones to the selector bycomparingnd a panel of other bindingabilityies; we alsofdemonstheted by dot selected immunoblotting that the most reaclonesand selectove phage pepthee bound with high avidity the bacterial cell selector
The rapid growth of chemistry modification techniques has enabled the design and development of various peptide-based imaging agents with enhanced metabolic stability, favorable pharmacokinetics, improved binding affinity and selectivity, better imaging ability as well as biosafety.
Owing to the ultrastrong binding ability of H2S and Cu2+, the ratiometric sensor not only exhibits high selectivity to H2S against other anions, thiols and biological species, which allows detection of H2S in serum sample with satisfied recovery, but also possesses the distinct feature of reversible sensing.
The binding ability was also evaluated, and the findings demonstrated high glucose binding and selectivity of imprinted particles compared to NIPs.
In this study, we developed an RNA aptamer-based AuNP sensor for the detection of theophylline in serum, combining the high binding affinity and selectivity of a theophylline RNA aptamer and the fluorescence quenching ability of AuNPs.
After labeling with reporter fluorescent groups, the oligonucleotides preserved their abilities to fold into a quadruplex structure and to interact with metal cations with binding affinity and selectivity comparable with that of unmodified oligonucleotides [ 29, 40, 172, 173].
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