Owing to its diversified structures, high affinity, and specificity for binding a wide range of non-nucleic acid targets, aptamer is a useful molecular recognition tool for the design of various biosensors.
After a short, general physico-chemical introduction to CNTs, we introduce different methods for CNT surface modification, facilitating their dispersions in physiological solutions, on the one hand, and binding a wide range of molecules or drug-loaded liposomes, on the other.
Our results demonstrate the high affinity that GO has for binding a wide range of aqueous metals, and the results can be used to estimate with a reasonable degree of certainty the distribution of metals in complex GO-bearing environmental or engineered systems.
Bet v 1 has a Y-shaped, solvent accessible hydrophobic cavity traversing the core of the molecule, capable of binding a wide range of ligands.
In contrast, batch B showed a CD spectrum typical for Bet v 1. Crystallization of several Bet v 1 isofoms revealed that the core of the protein is traversed by Y-shaped, solvent accessible, hydrophobic cavity capable of binding a wide range of ligands [24], [25], [26].
Aptamers are single-stranded oligonucleotides with a size of 15 60 nucleotides selectively binding a wide range of biomolecules, including whole cells.
The claMP Tag is capable of binding a wide range of transition metals, including many species that are used to enable imaging and therapeutic applications, under conditions amenable to retention of higher-order protein structure.
In addition to transcription factor binding, a wide range of other biological phenomena can be investigated, such as chromosome conformation, genetic variation, and RNA expression (RNA-seq) to detect, for instance, differential splicing, microRNA and other non-coding RNAs [ 3, 30, 31].
Following this, the binding of a wider range of concentrations (3 100 nM) of BODIPY-TMR-CGP to the native (unlabelled) human β1-adrenoceptor was assessed.
Heterozygosity at MHC loci may therefore enhance resistance to infectious diseases by binding and presenting a wider range of antigens to T-cells on the one hand [ 1], while on the other, generating a more diverse T-cell receptor repertoire during T-cell maturation [ 2- 4].
