Sentence examples for binding a number of from inspiring English sources

By inducing RNA-chromatin binding a number of RNA-dependent activities can be dissected: (i) The RNA-induced compaction or decondensation of chromatin, (ii) identification of RNA-interacting chromatin modifiers that set epigenetic signals such as posttranslational histone modifications, and (iii) nuclear relocation of a genomic locus targeted by the tethered RNA.

In principle, the methods should be interpretable in a similar fashion, which can be exploited to reveal structural features that are important for binding a number of desired targets.

It acts as a scaffold, binding a number of other proteins several of which have been shown to be independent risk factors for major mental illness (reviewed in ref (4)).

To investigate the effect of lower pH on ligand binding, a number of ligands tested at pH 7.4 were reexamined for binding to RKIP at pH 6.0.

After ligand binding, a number of modifications occurred in Notch receptors, including a proteolytic cleavage operated by a γ-secretase complex that ultimately releases the intracellular portion (active form) of Notch receptors (Notch intracellular domain (NICD)) from the plasma membrane.

To assess the effect of cell-surface proteolytic activity on plg binding, a number of experiments were performed on MCF-7 cells with modulated active and inactive exogenous uPA levels.

It has been reported that PKCε, both in activated and non-activated form, is capable of binding a large number of cellular molecules [32], [33].

M11L exhibits only minimal movement in the binding groove when binding a BH3 motif ligand, and displays high-affinity binding to a number of point mutants of Bak BH3 motif.

It is thus likely that Ste11 regulates the majority of pheromone-regulated genes, perhaps in some cases via co-operative binding to a number of relatively weak binding sites as previously reported [ 14].

From these data we reasoned that although individual examples for composite CTCT/TR binding elements are not a general feature of CTCF binding regions, a number of functional TRE motifs in the vicinity of CTCF binding sites might exist.

This type of analysis has been previously applied to SPR analysis of IgM binding (Cooper and Williams, 1999) as well as analysis of pentavalent cholera-toxin binding to a number of different gangliosides (Kuziemko et al., 1996).