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Eater is another pattern recognition receptor for binding a broad range of bacterial pathogens and mediating phagocytosis in Drosophila cellular immune responses [ 74].
The conformational changes experimentally observed in the enzymes by binding a broad range of ligands can be predicted by the most cooperative lowest frequency modes of motion by ANM, where the hinges are the key mechanistic regions of the structure that control the conformational ensemble.
In order to provide coverage against a large variety of potential antigens, the B cell-encoded antibody repertoire is incredibly diverse, estimated to comprise >10 immunoglobulins with distinct variable domain sequences in human serum, resulting in an antibody population capable of binding a broad range of antigens with high affinity and specificity.
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To be effective, any treaty should be legally binding and cover a broad range of weapons, including ammunition.
Conditional and regulated chromatin proteins such as transcription factors with sequence-specific DNA-binding domains indeed cover a broad range of ICPs.
We know of no previous study that has systematically examined action binding across a broad range of action-outcome delays (whereas outcome (tone) binding (Haggard et al., 2002) and compound measures, which do not distinguish between tone binding and action binding (e.g. Humphreys & Buehner, 2009), have been studied across a broad range of action-outcome intervals).
Already before treatment, there was robust antibody binding to a broad range of staphylococcal antigens.
The conformational adaptability and the allosteric fatty acids-induced regulation facilitate the binding of a broad range of pharmaceutical drugs, affecting their availability and biological efficacy (Curry 2009).
Applications for CORG cover a broad range from studying evolution of DNA binding sites and promoter constitution to the discovery of new regulatory sequence elements (e.g. microRNAs and binding sites).
These sites cover a broad range of molecular functional categories, including 795 active sites, 1369 ligand binding sites, 1498 protein protein binding sites, 171 metal binding sites, 41 post-translational modification sites, and 113 sites with miscellaneous functions.
The biologically most important binding functions are deduced from a small set of compounds that cover a broad range of activity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com