Sentence examples for binders to small molecules from inspiring English sources

An elegant solution for semiquantitatively analyzing and identifying protein binders to small molecules is to immobilize the small molecules on the chip, and subsequently measure the binding of the target proteins followed by elution to LC-MS [ 123].

The main strengths of the concept are that a small set of polypeptides can be used to develop binder molecules for any protein by conjugation to small molecules or peptides with only modest binding capacities, and that the binder molecules target the proteins that the small molecules recognise but with much improved affinity and selectivity.

Signaling molecules for communication between artificial cell-mimics have so far been limited to small molecules.

Towards this goal, a wide range of synthetic DNA binders, from small molecules to larger peptides, have been developed over the years.

Riboswitches modulate gene expression in response to small-molecule ligands.

The high-throughput docking of up to 106 small molecules followed by scoring based on implicit-solvent force field can robustly identify micromolar binders using a rigid protein target.

To that end, the next step for the Carolina researchers will be to introduce other small molecules to see how the water molecules interact with them.

This is particularly important when vaccinating against TAAs, as they are often weak or only intermediate binders to HLA molecules [ 112– 112].

Although the polypeptide itself is a weak binder, it is covalently linked to the small molecule which binds to the protein, and the entropic penalty associated with the polypeptide protein interaction has therefore been eliminated or, at least, drastically reduced [ 16].

However, the efforts needed to develop small molecule binders with high affinity and specificity are substantial.

The development of binder molecules based on small molecules depend primarily on experience in organic synthesis whereas the development of binder molecules based on peptides depend on peptide synthesis and are by comparison straightforward to prepare.