Sentence examples for binders may be a from inspiring English sources

Given that restoring exPGRN levels using SORT1 antagonists can potentially trigger off-target effects related to NTS (29), lipoprotein lipase (30) and LDL-receptor-associated protein (31) function and cause undesirable clinical side-effects, modulating the PGRN SORT1 interaction via PGRN-specific binders may be a promising approach.

Multiple conformations of switch II have been observed, suggesting that switch II pocket (SIIP) binders may be capable of engaging a range of KRAS conformations.

The complexing agents or binders may be cyclic or open-chained but successful binders must be organized either by design or by conformation to provide stabilizing contacts with anions having a range of geometric features.

Whether these E2Bmin binders may be implicated in the regulation of Ash1 mRNA in vivo remains to be elucidated.

Although current phosphate binders may be effective, they have limitations and adverse effects that may compromise optimal treatment.

The large difference between the doses of lanthanum carbonate and previous binders may be explained, in part, by in vitro data that show that lanthanum carbonate binds phosphate ions with a higher affinity compared with other phosphate binders [ 13].

However, exosite binders may be linked to active site inhibitors to achieve highly potent and highly selective two-site binding inhibitors.

However, it should be noted that other calcium-sparing phosphate binders may be equally effective, and no evidence has compared sevelamer with alternative noncalcium phosphate binding compounds in calcific uremic arteriolopathy.

Reasons for nonadherence to medication regimens have been shown to be complex and multifactorial [ 4- 7], but the high daily tablet burden associated with most phosphate-binder medications may be a contributing factor [ 8, 9].

Molasses, an eco-friendly and relatively cheap binder may be used as a substitute for chemical binders.

Therefore, the use of alternative viscous liquids with chemical inertness and inherent conductivity as a pasting binder may be very helpful for improving the electroanalytical performance of the CPE[19].