We selected bohemine [32], roscovitine [33], and butyrolactone [24], which are purine analogs that bind within the ATP binding pocket.
The receptor epitope for the weak agonist antibody was subsequently mapped, and shown not to bind within the hormone binding site, but adjacent to it [ 39].
Anti-tuberculosis drugs can bind within the peptide binding grooves of HLA-B*57 01 HLA-B*57 016 HLA-A*02 06 HLA-A*02 06 and HLA-A*02 03 HLA-A*02 03ficity.
Recently, crystallographic evidence was provided that the detergent, β- d-octylglucoside, can bind within rhodopsin's retinal binding pocket thus stabilizing the Ops* conformation.
The results of molecular docking study shed light on the binding mode which exposed that HTMF bind within the hydrophobic pocket of the subdomain IIIA of BSA.
When several known factor Xa inhibitors were overlaid within the protein binding site, we found that they all bind within the groove formed by the S1 and S4 sub-pocket of fXa (Figure 10B).
What is not known is where anesthetics bind within the channels, and how this binding translates into increased channel opening.
In contrast with the activating antibodies and thyrotropin that bind to the TSHR extracellular region, synthetic SMLs bind within the transmembrane domain into an additional allosteric binding pocket.
This composite element was observed in Spi-B unique peaks and provides evidence that IRF factors might bind within a few base pairs of the Spi-B binding sequence.
Collectively, our results suggest that Wnt3a and Wnt3 bind within the E3-E4 regiof of LRP6 and are inhibited from binding by YW211.31.57 antibody.
While some PAS domains have ligand-binding pockets as part of their signaling function, these ligands commonly bind within a single PAS unit.
