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We show that such proteins can bind with the same high specificity as prefolded protein, but have a considerably lower binding free energy.
Monoclonal antibodies are structurally identical immunoglobulin molecules with identical epitope-specificity (all of them bind with the same epitope with same affinity) as against their polyclonal counterparts which have varying affinities for the same epitope.
All NS5A mutants studied were found to bind with the same relative interaction to CypA as WT NS5A (Figure 6A).
Thus rRH5 appears to bind with the same specificity as the native PfRH5, indicating that rRH5 contains an intact receptor-binding domain, as in the native protein.
EMSA reveals that WT and S31P bind with the same affinity to an 8oxoG C DNA oligonucleotide.
In summary, we have demonstrated that SF2B helicases bind with the same orientation as SF2A and SF1 helicases (schematically depicted in Figure 7).
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Since PfRH2a/b is involved in erythrocyte invasion with an erythrocyte binding role and the rPfRH240 region binds with the same specificity as the native protein, we tested if antibodies against rPfRH240 could block erythrocyte invasion.
Regardless of whether monosites or heterosites are used, both NHR bound with the same relative degree to each binding site (Table S4 .What discrepancies were attributable to a small number of low order binding sites of approximately 1.5 2 fold enrichment where occupancy of the heterodimer partner could not be detected.
A closely related antibody from the same donor did yield crystals when bound with the same HA, giving us an independent validation of the cryoEM results.The two structures also augment our understanding of receptor-binding site recognition by antibodies that neutralize a wide range of influenza-virus variants.
For the second case study, we measure the throughput bound with the same network configuration as the first case but with three different BT distribution patterns: random distribution, regular distribution, and clustered distribution.
Apply Lemma 3 to Theorem 14. (i) Note that as n → ∞, K + ( n ) converges weakly to H+, the Fréchet Hoeffding upper bound with the same marginals F and G, and that (F- 1(Z), G- 1(Z)) ∼ H+.
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combined with the same
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connects with the same
bind with the unbound
bind with the HLA-A2-restricted
bind with the untranslated
bind with the pr
bind with the human
bind with the opposite
bind with the methylated
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