Sentence examples for bind with the active from inspiring English sources

In addition, Hirudin is the most potent natural inhibitor of thrombin, which possesses a specific activity to bind with the active site and fibrinogen-binding exosite 1 of thrombin and cleave fibrinogen and PAR-1 (Table 2) [ 83].

Increase in catalytic activity with increasing temperature could be rationalized that at higher temperature, phenyl ring of the borane moiety cannot bind with the active metal center which is beneficial for better activity.

It is directly related with the competition abilities of hydrogen ions with metal ions to bind with the active sites on the biosorbent surface.

Inhibitors bind with the active or allosteric site of HIV RT based on their chemical nature whether they are analogs of nucleoside or non-nucleoside, respectively.

Having a structure more similar to that of L-tyrosine than that of 4-TBP, RD was speculated to bind with the active center of tyrosinase.

Thus, we consider the fact that clusterin, as a chaperon molecule, has been found to bind with the active form of Bax under apoptotic stimuli inhibiting its dimerization in the mitochondria and block apoptosis.

One of the more interesting findings is that NP1 was only bound with the active, processed form of LC3β (LC3β-II).

A recent study using a crystal structure of the catalytic domain of GLS1 complexed with DON reported that it covalently binds with the active site Ser286 and interacts with residues such as Tyr249, Asn335, Glu381, Asn388, Tyr414, Tyr466, and Val484.

To visualize the protein protein interaction network of the protein PF0847, STRING was employed, and the obtained network is shown in Figure 8. Continuing with the STRING results, we found that geneticin bound to the eubacterial 16S rRNA A-site (PDB code: 1MWL) binds with the active site of the target protein PF0847 (Fig. 9).

It is true that the ClpX structure cited in our original submission is in the apo state, but later structural work from the Sauer group showed that this hexamer conformation is compatible with nucleotide binding, with ATPγS bound to the active sites of the four "closed" (referred to by the Sauer group as nucleotide- loadable") chainucleotide- loadablePDB 4I81, Stinson et al. chains013).

Docking simulations in this study show that TDIs of P450 1A1 bind with the enzyme's active site cavity with the acetylene group facing toward the heme, whereas for all the tested molecules docked into the active site cavity of P450 1A2, the acetylene group is oriented away from the heme leading to the compounds acting as competitive inhibitors of this enzyme.