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Although the compounds are unable to form hydrogen bonds with the hPR in the D-ring region, they bind with superior affinity and exert stronger in vivo progestational effects than progesterone itself.
Similar(59)
Therefore, monoclonal antibodies (mAbs) with superior affinity for ovine PrP in Western blot (WB) were sought.
The ELISA results indicated the VHH nanobody after renaturation was bioactive and could specially bind CTGF with a superior affinity to mAb.
1A and B bind with approximately equal affinity, although the exact affinity could not be obtained as each DNA binds more than one MA.
These analogues bind with extraordinary affinity relative to reactants.
Indeed, dextro enantiomers bind with high affinity σ1 receptor while opposite enantiomers bind opioid receptors.
First, they bind with high affinity and specificity to a wide variety of proteins.
Aminocyclohexyl indoles bind with high affinity and specificity toward the serotonin transporter (SERT).
The tightest binding design, named Spider Roll, bound with an affinity of 100 μM.
Heparin-binding studies showed that all fragments bound with low affinity to heparin.
Importantly, ADP binds with low affinity, which is insufficient to interfere with binding or release of these high affinity inhibitors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com