Sentence examples for bind with subnanomolar affinity from inspiring English sources

Endomab-B1, a monoclonal antibody has recently been reported to bind with subnanomolar affinity for the ETB receptor, competed with ET-1 binding with greater efficacy than BQ788, and functions as an antagonist to block the ET 1-induced IP3-calcium signalling pathway (Allard ET 1-induced).

U1A binds with subnanomolar affinity to SLII, and as Figure 3A shows, addition of U2A′ modestly increases the affinity.

MultiGraft Interface generated an epitope-scaffold that bound 2F5 with subnanomolar affinity (K(D) = 400 pM) and that interacted with the antibody CDR H3 loop through computationally designed contacts.

We describe the expression and purification of the second Ig-like domain of human TrkB (TrkBIg2) and show, using surface plasmon resonance, that this domain is sufficient to bind BDNF and NT-4 with subnanomolar affinity.

ABT-737 (Abbott Laboratories) binds to Bcl-2, Bcl-xL and Bcl-w with subnanomolar affinity (Ki <1 nM), while AT-101 (Ascenta Therapeutics) binds to Bcl-2 and Bcl-xL less potently (Ki >300 nM) but has somewhat higher avidity for Mcl1 (Ki ~180nM) (28, 28).

A nanobody to GFP (or YFP), known as GFP binding protein (GBP), is only ∼13 kDa and 1.5 × 2.5 nm with subnanomolar affinity.

The design and synthesis of a new type of 5-HT3 ligand with subnanomolar affinity are described.

Here we describe the isolation of PDGFRβ-specific Affibody molecules with subnanomolar affinity.

We found that screening a 7-mer library results in convergence onto a single peptide sequence with subnanomolar affinity for these dyes.

Antibody phage display starting with immune libraries and followed by affinity maturation is a powerful strategy to generate high affinity human antibodies to difficult targets, in this case shown by the creation of a highly specific antibody with subnanomolar affinity to a very small epitope consisting of four amino acids.

As a result, ssDNA MRE with subnanomolar affinity and high specificity was identified after twelve rounds of selection.