Competition experiments showed that the two receptors cross-compete and that the t-CD81 binds with stronger affinity than the human molecule.
In this respect, HLA-A*03, which on the contrary binds with stronger affinity than HLA-A*26 to LILRB1 [ 20] and also ligates to the NK cell receptor KIR3DL2 [ 22], could be of interest as a potential protective allele with an observed negative association to BD and thus should be investigated in further larger patient cohorts.
The allotypic diversity of rabbit immunoglobulins prompted us to compare different rabbit immune repertoires for the generation and humanization of monoclonal antibodies that bind with strong affinity to antigens involved in tumor angiogenesis.
In this paper, we design a fullerene to mimic the structure of μ-conotoxin, which has been shown to bind with strong affinity to NavAb [16, 17].
The HNF4 nuclear receptor is able to bind, with strong affinity, to an alternative HNF4 specific half-site with the 5'-AG TCCA-3' sequence [ 32, 33].
OPG inhibits bone resorption and binds with strong affinity to its ligand, RANKL, thereby preventing RANKL binding to its receptor, RANK [ 11, 13, 14].
This suggests that PIASy binds with strong affinity to native and SUMO-modified VHL but had little or less affinity for the ubiquitin-modified or dimerized SUMO-modified VHL (supporting the proposed model in Figure 3H).
MRFAP1 binds with strong affinity to mortality factor 4 like 1 (MRG15) [ 17].
These observations, in combination with our previous data showing that PDCD10 selectively binds to phosphatidylinostiol bis- and trisphosphates, but binds PtdIns 3,4,5 P3 with strongest affinity, led us to hypothesize that this area could be a potential amphipathic helix that may play a role in PtdIns 3,4,5 P3 binding [28].
These data lead to the conclusion that, whether LcrV is immobilized or free in solution, it binds to IFNγ with strong affinity.
