Sentence examples for bind with lower affinity from inspiring English sources

Ligands that bind stably to G-protein uncoupled PTH1R [e.g. PTH (1-34)] produce a greater cAMP response for extended times after initial binding than ligands that bind with lower affinity [e.g., PTHrP (1-36)].

Glycine substitution of this residue destroyed binding to this site, whereas notably, TtgR has a second "general" binding site to which phloretin and other drugs bind with lower affinity, which is not dependent upon charged residues (29).

Strikingly, 45% of the peaks (62/138) contain a chCaRE sequence that we predict would bind with high affinity to CaRF, while an additional 19.5% (27/138) have sequences that we predict would bind with lower affinity.

The first approach requires design of analogues of biotin which bind with lower affinity to avidin.

This observation is consistent with the hypothesis that under normal physiological conditions, Armet and Creld2 are able to bind to the KDEL-R and remain within the ER (40); however, it is believed that KDEL-variants bind with lower affinity than KDEL itself (38).

This implies that target 5' XXXGGGXXX 3' binds to the same ZFP with higher binding affinity in comparison to the target 5' XXXGTAXXX 3' which binds with lower affinity to the same protein [ 30].

Inhibitor binding assays showed that both of the thermostabilised SERT mutants bound [125I]RTI55 (β-CIT) with affinity similar to that of the wild-type transporter, although cocaine bound with increased affinity (17- to 56-fold) whilst ibogaine, imipramine and paroxetine all bound with lower affinity (up to 90-fold).

Kaiso is actually bimodal in that it also binds with lower affinity to a conventional DNA motif [55].

These data are in some agreement with our in vitro binding assays but as compared to the non-phosphorylated Atx1 ULM, the phosphorylated peptide binds with lower affinity.

Importantly, it cross-reacted with the mouse peptide although it is bound with lower affinity to the Aq molecule than the corresponding rat peptide.

Follistatin also binds with lower affinity to other TGF-β superfamily members including growth and differentiation factor 9 (GDF9), myostatin and BMP 2, 5, 7 and 8 [ 24].