Sentence examples for bind with low affinity from inspiring English sources

As a result of the limited number of residues contacting their binding partner, SLiMs bind with low affinity [usually between 1.0 and 150 micromolar (Diella et al., 2008)] distinguishing them from domain domain interactions that often have an affinity in the nanomolar range (Neduva et al., 2005).

In some cases, including those target regions with NL Q<100 NtcA could bind with low affinity, so that relevant binding would require a higher concentration of NtcA, an additional factor, or both (see Figure  3).

Instead, there are many B cells that bind with low affinity to these determinants, a binding which is insufficient for their deletion or inactivation.

Indeed, inspection of the solution NMR structure of the isolated murine SH3C does not show an obvious binding grove, suggesting that this domain may not bind to, or bind with low affinity, to target proteins [ 176].

Although these conserved epitopes are often weakly immunogenic, the GC reaction is surprisingly permissive for the continued survival/proliferation of B cells that bind with low affinity or react to cryptic epitopes, increasing their chance of memory recruitment.

A likely explanation for this result is suggested by a recent report showing that Cw4 (conserved on this patient melanoma cells) can bind with low affinity KIR2DL2/3 [24].

Heparin-binding studies showed that all fragments bound with low affinity to heparin.

The applied growth conditions in complex rich medium might not be suitable for the detection of all PdhR-DNA interactions, although the overproduction of PdhRhis should facilitate binding, also to DNA fragments which might be bound with low affinity.

Importantly, ADP binds with low affinity, which is insufficient to interfere with binding or release of these high affinity inhibitors.

BIAcore analysis demonstrated that, with the extracellular domain (ECD) of NP-1 immobilized at low density, VEGF165 bound with low affinity (K d) = 2 microm) and fast kinetics.

We previously identified the crystal structures of non-canonical peptides in complex with MHC class I (one bound with low affinity and the other with high affinity, but utilizing novel peptide anchors and MHC pockets).