Sentence examples for bind with increased affinity from inspiring English sources

We then experimentally test the approach by designing extensions for p53 and dystroglycan-based peptides predicted to bind with increased affinity to the Mdm2 oncoprotein and to dystrophin, respectively.

Further epitope prediction analysis revealed a number of 15-meric epitopes, including Tyr-containing peptides from C-terminal, that can bind with increased affinity class II MHC groove, thus increasing the propensity of inducing MHC class II-restricted CD4+ T cells specific for Tyr-containing α-Syn C-terminal fragments.

On a speculative plane, at low pH, albumin might bind with increased affinity to a TGN protein or lipid, resulting in enhanced concentration and sorting into export carriers.

Then toxin oligomers bind with increased affinity to GPI-anchored receptors and create pores in the midgut membrane, leading to osmotic shock and cell death.

When compared with rituximab, it binds with increased affinity and has a longer dissociation time, both of which improves its complement-mediated cellular cytotoxicity [ 16, 17].

The resulting BH3 domain alpha-helix is more rigid, protease-resistant, cell permeable and binds with increased affinity to Bcl-2.

Our results show that this is indeed the case, where the decapeptides AEGPT AEEVD and AEGPT MEEVD were found to bind with increasing affinity (Kd=14.8±0.7 μM and Kd=4.2±0.5 μM respectively; Figures 5d and 5e) relative to the wild-type sequence decapeptide (Kd=28.9±3.1 μM; Figure 4c).

The inhibition of FcRn using engineered antibodies that bind to this receptor with increased affinity through their Fc region can be exploited to treat antibody mediated autoimmunity.

In summary, the F1A5-elicited T cells bound to the AH1 antigen with increased affinity, which may explain the previously described improved effector function exhibited by T cells responding to this peptide vaccine [ 17].

Indeed, studies of the PNKP FHA domain have shown that mono- di- and tri- phosphorylated XRCC1 peptides bind with progressively increasing affinity [32].

Sant 7 is a mutated form of IL-6 that binds to the IL-6R with an increased affinity that results in an inactive configuration of the receptor (Demartis et al, 1996).